DDI-Predictor is a website dedicated to quantitative prediction of the impact on drug exposure of:
- Drug-drug interactions mediated by cytochromes P450 3A4, 2D6, 2C9, 2C19 and 1A2
- Genetic polymorphism of these cytochromes
- Combined effect of drug interaction and cytochrome polymorphism
- Drug-drug interactions in cirrhotic patients
DDI-Predictor is NOT a database in the usual sense. DDI-Predictor is able to make quantitative predictions of drug exposure e.g. in case of drug-drug interaction even if this interaction has not been studied. This is the distinctive feature of DDI-Predictor. The predictions are made using static equations of physiologically-based pharmacokinetic models.
Adjusting drug dose
The predictions are made under the form of AUC ratios.
Estimating the dose to be given is very simple in most cases:
Adjusted dose = (Current or usual dose) / (AUC ratio)
For prodrugs (non exhaustive list : codeine, clopidrogrel, losartan), the formula becomes:
Adjusted dose = (Current or usual dose) * (AUC ratio)
This is the Academic version of DDI-Predictor, free of charge.
For drug development purpose in the context of pharmaceutical industry see DDPred.com