AUCuCIR
Unbound AUC of the substrate in a cirrhotic patient over the dosing interval at steady-state.
AUCu
Unbound Area Under the substrate Concentration in a non-cirrhotic patient over the dosing interval at steady-state.
AUCuCIR / AUCu
This ratio is useful for adapting the initial dose of the substrate to be given to a cirrhotic patient.
AUCCIR
AUC of the substrate in a cirrhotic patient over the dosing interval at steady-state.
AUC
Area Under the substrate Concentration in a non-cirrhotic patient over the dosing interval at steady-state.
AUCCIR / AUC
This ratio is useful to compare predicted vs observed data, because measurements are usually based on total rather than unbound concentrations.