AUC of the substrate given with an inhibitor or an inducer
AUCXM* / AUCXM
This ratio is useful for adapting the dose of the substrate in a patient in whom an optimal dose had been found but an interacting drug is added to the current treatment.
AUCXM* / AUCEM
This ratio is useful for adapting the initial dose of the substrate to be given to a patient whose genotype is known.