DDI & Cirrhosis

Combined impact of drug-drug interaction and cirrhosis

substrate

Start typing the name of a drug or scroll down the list to choose one

substrate

Fraction metabolized by each CYP
Adults
Children
 
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Inducer

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inducer

Induction potency with respect to each CYP
 
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OR

Inhibitor

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inhibitor

Inhibition potency with respect to each CYP
 
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AUC ratios

Child-Pugh Class
 
Show AUC ratios' interindividual distribution (5th to 95th percentiles)
 
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Definitions

AUCuCIR* / AUCuCIR
This ratio is useful for adapting the dose of the substrate in a cirrhotic patient in whom an optimal dose had been found but an interacting drug is added to the current treatment.
AUCuCIR* / AUCu
This ratio is useful for adapting the initial dose of the substrate to be given to a cirrhotic patient in whom the interacting drug is already prescribed.