DDI

Impact of Drug-drug interactions on drug exposure

Age of patient

Age >= 2 years

Age < 2 years  ( months)

Age

months

Adult

substrate

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CYP metabolism is a minor pathway for the elimination of this drug. No relevant interaction with CYP inhibitors or inducers is expected.
Glucuronidation is a major pathway for the elimination of this drug. No relevant interaction with CYP inhibitors is expected. Some inducers (e.g. rifampicin) may lower its exposure.

substrate

Fraction metabolized by each CYP
Adults
Children
 
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Interactor

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interactor

Induction or Inhibition potency with respect to each CYP
 
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AUC ratio

 
Show AUC ratios' interindividual distribution (5th to 95th percentiles)
 
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Definitions

AUC
Area Under the substrate Concentration in blood or plasma over the dosing interval at steady-state
AUC*
AUC of the substrate given with an inhibitor or an inducer