DDI

Impact of Drug-drug interactions on drug exposure

Age of patient

Age >= 2 years

Age < 2 years  ( months)

Age

months

Adult

substrate

Start typing the name of a drug or scroll down the list to choose one

substrate

Fraction metabolized by each CYP
Adults
Children
 
Warning!

Inducer

Start typing the name of a drug or scroll down the list to choose one

inducer

Induction potency with respect to each CYP
 
Warning!
OR

Inhibitor

Start typing the name of a drug or scroll down the list to choose one

inhibitor

Inhibition potency with respect to each CYP
 
Warning!
 

AUC ratio

 
Show AUC ratios' interindividual distribution (5th to 95th percentiles)
 
Reset

Definitions

AUC
Area Under the substrate Concentration in blood or plasma over the dosing interval at steady-state
AUC*
AUC of the substrate given with an inhibitor or an inducer